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Senior Process Chemist CMC

Company: Arrowhead Pharmaceuticals, Inc
Location: Madison
Posted on: March 19, 2023

Job Description:

The PositionArrowhead is seeking a process development chemist to join our Chemistry, Manufacturing and Controls group. The successful candidate will be tasked with developing new scaling methods for the manufacturing of small molecules in-house scale-up campaigns.Responsibilities

  • Develop scalable processes for small molecule components of RNA drug conjugates as well as bioconjugations strategies to attach these moieties onto oligonucleotides
  • Conduct laboratory scale experiments to develop new chemistries for the manufacturing of oligonucleotides
  • Use analytical methods to monitor and understand the impact of process changes on the yield and impurity profile of target compounds
  • Effectively document both laboratory and scale up activities
  • Track progress against project plans, generate regular status updates, and communicate progress and issues to management
  • Be creative and innovation in problem solvingRequirements:
    • PhD in organic chemistry with 0 to 3 years of pharmaceutical experience
    • Working knowledge of common analytical techniques, including the ability to independently conduct the analyses and accurately interpret the obtained data
    • Experience manufacturing materials under GLP protocolsPreferred:
      • Experience working with solid phase synthesis, particularly oligonucleotides, and with large molecule drug candidates
      • Understanding of the drug development process and governing regulations
      • Experience with summarizing developmental activities for inclusion in the CMC sections of regulatory documents

Keywords: Arrowhead Pharmaceuticals, Inc, Madison , Senior Process Chemist CMC, Other , Madison, Wisconsin

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